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Vascular reworking in ALS While Mind perivascular fibroblast cells weren't Formerly looked upon as involved with the etiology of amyotrophic lateral sclerosis (ALS), their action exhibits a promising early indication of disease symptoms. Månberg and colleagues clearly show that perivascular fibroblast cells come to be activated in clients with sporadic ALS and in mouse designs at an early phase that precedes neuronal loss.